front pharmacol impact factor{ keyword }

European Journal of Pharmacology - Impact Factor, Overall Ranking 26/06/2023 Fernblock prevents dermal cell damage induced by visible and infrared a radiation. Frontiers in Pharmacology is a journal published by Frontiers Media S.A.. Associate Editors can recommend the rejection of an article to the Chief Editor, who needs to check that the authors rights have been upheld during the peer-review process, and who can then ultimately reject the article if it is of insufficient quality, has objective errors or if the authors were unreasonably unwilling to address the points raised during the review. Among all pharmaceutical dosage forms, sterile injectable products have a higher risk of shortage than other forms. Most of the events that contribute to intrinsic and extrinsic aging, such as mitochondrial dysfunction, inflammation, and the abnormality of extracellular matrix homeostasis, are a consequence of oxidative stress (Kammeyer and Luiten, 2015; Lephart, 2016). Fac. 2023 Jun;31(6):948-954. doi: 10.1016/j.jsps.2023.04.019. Recently, in 2019, Nguyen et al. Please check the "About" pages of each specialty section for further information. However, a relationship between air pollution and skin aging was first shown in the SALIA study (SALIA, study on the influence of air pollution on lung function, inflammation, and aging), an epidemiological study of 400 Caucasian women aged 7080 years, from 2008 to 2009, which indicated that exposure to trafc-related PM contributes to skin aging (Vierktter et al., 2010). On the other hand, AhR in the non-canonical pathway also plays a critical role in regulated T cell responses. Manuscripts are peer-reviewed by the Associate and Review Editors of the Edited by: Andrzej T. Slominski, University of Alabama at Birmingham, United States, Reviewed by: Zorica Janjetovic, University of Alabama at Birmingham, United States; Anna A. Brozyna, Nicolaus Copernicus University, Poland, This article was submitted to Experimental Pharmacology and Drug Discovery, a section of the journal Frontiers in Pharmacology. Authors Kenji Onda 1 . Another crucial factor in skin aging is the increased expression of matrix metalloproteinases (MMPs) and decreased expression of MMP inhibitors (TIMP). (2015). Pharmacology | Karger Publishers Chronic exposure to PM increased the risk of developing respiratory and cardiovascular diseases, as well as cancer (Lelieveld et al., 2015; Hamanaka and Mutlu, 2018). Besides this, UVA accelerates the cellular metabolism of B[a]P, which leads to a higher increase of B[a]P derivatives. Published online 2021 Aug 23. . 1Department of Histology and Pathology, Faculty of Medicine, University of Mlaga, Mlaga, Spain, 3Dermatology Service, Miguel Servet Hospital, Zaragoza, Spain, 4Medicine and Medical Specialties Department, Alcala University, Madrid, Spain, 5Biology Department, Sciences School, Autonoma University, Madrid, Spain. Methotrexate-associated pneumonitis and rheumatoid arthritis-interstitial lung disease: Current concepts for the diagnosis and treatment. Pretreatment with inhibitors of COX2 and PGE2 attenuated the decrease of FLG. The .gov means its official. FLG contributes to epidermal hydration (Lee et al., 2012). Hls A., Sugiri D., Fuks K., Krutmann J., Schikowski T. (2018). Oxidative stress is the leading cause of photoaging, and it is involved in several diseases, including cancer (Kammeyer and Luiten, 2015). Inclusion in an NLM database does not imply endorsement of, or agreement with, Also, O3 induces damage to the extracellular matrix increasing MMP-9 accompanied by a decrease in collagen types I and III (Fuks et al., 2019). These stressors, combined with internal factors, are responsible for cutaneous aging. Outdoor air pollution originates from natural and anthropogenic sources. The aryl hydrocarbon receptor (AHR), a novel regulator of human melanogenesis. Bethesda, MD 20894, Web Policies Lung involvement and drug-induced lung disease in patients with rheumatoid arthritis. 2023. By TEM, PM2.5 has been found inside HaCat cells in the mitochondria, cytoplasm, and nucleus also providing a molecular insight into PM2.5-induced skin injury (Zhang et al., 2017b) ( Jin S. P., Li Z., Choi E. K., Lee S., Kim Y. K., Seo E. Y., et al. ). (2013). (2015. a). In addition to the canonical AhR pathway, the activation of AhR affects NF-B pathways. Supply issues consist of manufacturing problems, unavailability of raw materials, logistic problems, and business problems. Frontiers in PharmacologySCI "FRONT PHARMACOL" "FRONT PHARMACOL" 2022-2023 5.988 3.1% Journal's Impact Ranking Frontiers in Pharmacology Journal's Impact Ranking Key Factor Analysis One-click to visualize your research performance Researchain.net Highly Cited Articles Frontiers in Pharmacology High Impact Research Articles Display records per page Search: Previous 1 2 3 4 5 10 Next The impact of air pollutants, UV exposure and geographic location on vitamin D deficiency. The publisher of Frontiers in Pharmacology is Frontiers Media S.A.. Also, IcdP and UVA1 affected mitochondria by triggering superoxide production and membrane depolarization. Those major targets offer the opportunity to segment the field not only in studies considering pure basic topics but also by integrating basic and clinical science. (2013). Skin aging impairs the skin barrier (Kim et al., 2013; Wang and Dreesen, 2018). Of the PHA, B[a]P, and indeno[1,2,3-cd]pyrene (IcdP) showed the highest phototoxicity at low concentrations (nanomoles per liter). As mentioned earlier, WHO (World Health Organization, 2012) considers six types of air pollutants, but the six types could be classified attending to the source in four groups: particulate matter (PM), persistent organic pollutants (POP) (e.g., dioxins), gaseous pollutants (e.g., CO, SO2, NOx, VOCs, O3), and heavy metals (e.g., lead, mercury). Here are some critical parameters that are considered while calculating the acceptance rate: The simplest way to find out the acceptance rate or rejection rate of a Journal/Conference is to check with the journal's/conference's editorial team through emails or through the official website. Exposure of human skin to benzo[a]pyrene: role of CYP1A1 and aryl hydrocarbon receptor in oxidative stress generation. Table 1 the following Readiness of health facilities to manage individuals infected with COVID-19, Uganda, June 2021. https://www.gmp-compliance.org/gmp-news/handling-of-apis-and-excipients- Abdelrahman A. Therefore, long-term exposure to tropospheric O3 can contribute to skin aging ( Frontiers algorithms are constantly fine-tuned to better match Review Editors with manuscripts, and additional checks are being coded into the platform, for example regarding conflicts of interest. The work can be freely shared and adapted provided that appropriate credit is given and any changes specified. The aryl hydrocarbon receptor (AhR) is a cytosolic ligand-activated transcription factor expressed in the skin (keratinocytes, fibroblasts, and melanocytes) as well as in regulatory T cells. can be used for citing, indexing, abstraction, and referencing purposes. Table 1 Assessing human exposure to organic pollutants in the indoor environment. However, pollution caused by anthropogenic sources is overcome by contamination from natural sources. Check out our author guidelines for everything you need to know about submission, from choosing a journal and section to preparing your manuscript. Larigot L., Juricek L., Dairou J., Coumoul X. Ultimately, all the processes previously related produce direct and indirect toxicity to the skin (Mancebo and Wang, 2015; Krutmann et al., 2017). The intercellular lipid determines the permeability of the stratum corneum. Frontiers in Pharmacology continues to rank among the world's top pharmacology journals in terms of influence and quality, as shown by our analysis of the 2017 Journal Citation Reports (JCR-2017; 2018, Clarivate Analytics), 2017 CiteScore edition (2018, Scopus, Elsevier) and other impact metrics. It is computed in the year 2023. AhR contributes to physiological and physiopathological processes in the skin and regulates cellular proliferation, inflammation, and melanogenesis (Eckers et al., 2016). A recent review has reported the impact of air pollution on humans. 10.1016/j.bfopcu.2016.05.004 Accessibility Environmental effects of ozone depletion, UV radiation and interactions with climate change: UNEP Environmental Effects Assessment Panel, update 2017, Vitamin D receptor, UVR, and skin cancer: a potential protective mechanism, Protective actions of vitamin D in UVB induced skin cancer, Mechanisms of aging and development-A new understanding of environmental damage to the skin and prevention with topical antioxidants, Synergistic damage by UVA radiation and pollutants, Vitamin D: dietary requirements and food fortification as a means of helping achieve adequate vitamin D status. Ozone (O3) is a fundamental component of the stratosphere, but it is also found in the troposphere. MMP-1 and -3 promoter variants are indicative of a common susceptibility for skin and lung aging: results from a cohort of elderly women (SALIA), Biomarkers of cellular senescence and skin aging. (2018). (2018). The site is secure. ODriscoll C. A., Gallo M. E., Fechner J. H., Schauer J. J., Mezrich J. D. (2019). The Associate Editor can also weigh in on the discussion and is asked to mediate the process to ensure a constructive revision stage. Melanogenesis in human skin following exposure to long-wave ultraviolet and visible light. Soeur J., Beladi J. P., Chollet C., Denat L., Dimitrov A., Jones C., et al. Frontiers in Pharmacology generally endorses the relevant principles described in the4 pillars of ethnopharmacologyfor all studies involving natural products submitted to all specialty sections in the journal. It is evaluated in the year 2023. The Convention of Stockholm in 2001 identified 12 POPs or the dirty dozen. According to the source, POPs can be grouped into three categories: i) pesticides that, although banned, are still used in some countries, ii) POPs whose origins are from the industry, like polychlorinated biphenyls (PCB), and iii) unintended industrial by-products. The PM (SRM1649b, a model of exposure to ambient urban PM urban dust, average diameter 10.5m) increases aging-related genes after the activation of AhR-MAPK signaling. Montagna W., Kirchner S., Carlisle K. (1989). In the stratosphere, it has a vital role in protecting against the ultraviolet radiation (UVR) of the sun. ) ( AlRuthia Y, Mohammed Almutiri N, Musa Almutairi R, Almohammed O, Alhamdan H, Ali El-Haddad S, Abdu Asiri Y. Saudi Pharm J. Eupafolin ameliorates COX-2 expression and PGE2 production in particulate pollutants-exposed human keratinocytes through ROS/MAPKs pathways. This pathology is characterized by hyperkeratinization and metaplasia of the sebaceous glands. Other means of exposure to PAH include food and drinking water contaminated by environmental sources. For more information on open access clickhere. Protective effects of topical vitamin C compound mixtures against ozone-induced damage in human skin. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Rudyak S. G., Usakin L. A., Tverye E. A., Orekhov A. S., Belushkina N. N., Paus R., et al. In addition, the surface of the skin is covered by a lipid film produced by the sebaceous glands in the dermis that is secreted through the pilosebaceous follicles. (B). Impact Factor is the most common scientometric index, which is defined by the number of citations of papers in two preceding years divided by the number of papers published in those years. Negative cellular effects of urban particulate matter on human keratinocytes are mediated by p38 mapk and nf-b-dependent expression of trpv 1. Unauthorized use of these marks is strictly prohibited. Frontiers has a number of procedures in place to support and ensure the quality of the research articles that are published: Only leading experts and established members of the research community are appointed to the Frontiers Editorial Boards. Astragali Radix and its compound formononetin ameliorate diesel particulate matter-induced skin barrier disruption by regulation of keratinocyte proliferation and apoptosis, The aryl hydrocarbon receptor as an immune-modulator of atmospheric particulate matter-mediated autoimmunity. ). Brief Research Report, Case Report, Clinical Trial, Community Case Study, Correction, Curriculum, Instruction, and Pedagogy, Data Report, Editorial, Erratum, General Commentary, Hypothesis & Theory, Methods, Mini Review, Opinion, Original Research, Perspective, Policy Brief, Policy and Practice Reviews, Review, Study Protocol, Systematic Review, Technology and Code. The increase in air pollution has harmful effects on human skin. Table 1 Skin pigmentation more prevalent in Yusho patients, Mitochondrial superoxide Mitochondrial membrane depolarization. article types: ). A., Saad A. Similarly, UVA activated NOX activity decreasing FLG expression (Valencia and Kochevar, 2008). The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Ozone exposure activates oxidative stress responses in murine skin, Nox1-based NADPH oxidase is the major source of UVA-induced reactive oxygen species in human keratinocytes. (2011). The study included 806 women from the SALIA cohort and 1,207 men and women from the BASE-II cohort. Valacchi G., Pagnin E., Corbacho A. M., Olano E., Davis P. A., Packer L., et al. Table 4 The United States Environmental Protection Administration (EPA) has included seven PAH in group B2 (probable human carcinogens): benzo anthracene, chrysene, benzo(a)pyrene, benzo(b)fluoranthene, benzo(k)fluoranthene, dibenzo(a,h)anthracene, and indene(1,2,3-cd)pyrene (Working Group on Polycyclic Aromatic Hydrocarbons, 2001). Synergistic effects of UVA and UVB radiation and benzo(a)pyrene (B[a]P) and particulate matter (PM) in the skin. Frontiers in Pharmacology Impact Score* 9.7 OFFICIAL WEBSITE Ranking & Metrics Research Impact Score*: 9.7 Impact Factor: 5.988 Citescore: 6.6 SCIMAGO SJR: 1.143 SCIMAGO H-index: 104 Research Ranking (Medicine) 293 Number of Best scientists*: 427 Documents by best scientists*: 580 Journal Information ISSN: 1663-9812 Publisher: (Slominski et al., 2004; Slominski et al., 2012a). Dbrowska A. K., Spano F., Derler S., Adlhart C., Spencer N. D., Rossi R. M. (2018). The specific components of the PM and their concentrations are not well understood (ODriscoll et al., 2019). Also, the skin is colonized by an abundant and diverse community of microbes, known as microbiome (Dbrowska et al., 2018). (2018). PM, PHA, and O3 also have a synergistic effect with solar radiation, so photodamage increases. PM2.5 can pass the pulmonary barrier and reach the blood. 4-HNE, 4-hydroxy-2-nonenal; AhR, aryl hydrocarbon receptor; B[a]P, benzo (a) pyrene; CCN1, cysteine-rich protein 61; CYP1A1, cytochrome P450 (CYP1A1); IL, interleukin; NF-kB, nuclear factor kappa B; Nrf2, nuclear factor erythroid 2-like 2; ROS, reactive oxygen species; TCDD, dioxin/2,3,7,8-tetrachlorodibenzo; TNF-, tumor necrosis factor. Vierktter A., Schikowski T., Sugiri D., Matsui M. S., Krmer U., Krutmann J. The latest ranking of Frontiers in Pharmacology is 3797. Activation of AP-1 stimulates collagen degrading by MMP and activates the nuclear factor kappa B (NF-B), an activator of the inflammatory response (Poljak and Dahmane, 2012). This research was funded by Spanish grants from Instituto de Salud Carlos III MINECO and Feder Funds (FIS: PI15/00974, PI18/00708, and PI18/00858). (2018). ). IS may decrease in 2023 as well. Copyright 2023 Onda, Honma and Masuyama. The latest impact score of Frontiers in Pharmacology is 5.35. The highest deficiencies in vitamin D have been found in the Middle East, Asia, and Northern Europe, respectively. Year. Frontiers in Pharmacology | Neuropharmacology 2019 Mar;38(3):949-954. doi: 10.1007/s10067-018-4355-0. Keywords: Check out Congress Announcements Journal of Cardiovascular Pharmacology - Impact Factor, Overall Ranking In general, individuals wear a skin that reflects several stages of extrinsic aging, superimposed on the level of intrinsic aging. The AHR represses nucleotide excision repair and apoptosis and contributes to UV-induced skin carcinogenesis. Quan C., Cho M. K., Perry D., Quan T. (2015). Very recently, Krutmann group (Fuks et al., 2019) addressed the effects of O3 in the skin in two densely urbanized areas of Germany: the area of the SALIA cohort in Ruhr area, and the BASE-II cohort in Berlin. Frontiers' philosophy is that all research is for the benefit of humankind. In this subgroup, a significant correlation between the upregulation of IL-1 in skin samples and PCB levels was found (Leijs et al., 2018) ( Only leading researchers acting as Associate Editors, who are not part of Frontiers staff, can make acceptance decisions based on reviews performed by external experts acting as Review Editors or reviewers. Impact Score 2022 of Frontiers in Pharmacology is 5.35. van Donkelaar A., Randall V., Martin R. V., Li C., Burnett R. T. (2019). Editors. ). Would you like email updates of new search results? Epub 2023 Apr 24. The reference values for PM10 are 20 and 50 g/m3, respectively, and 10 and 25 g/m3, respectively, for PM2.5 (World Health Organization, 2014). The exposition of high levels of PM2.5 was significantly associated with skin aging. In the area with high levels of PM2.5, the number of senile lentigines spots on cheeks and back of hands was 1.48 and 2.8 times higher, respectively, compared to the population exposed to the lower levels of PM2.5 (Peng et al., 2017) ( However, there are no reference values for them. Impact Factor Kwon K., Park S. H., Han B. S., Oh S. W., Lee S. E., Yoo J. (2017). Singh JA, Hossain A, Tanjong Ghogomu E, Mudano AS, Tugwell P, Wells GA. Cochrane Database Syst Rev. The role of TRPV1 channel in aged human skin. The deaths per year due to ambient (outdoor) air pollution reached 4.2 million in 2016. Airborne polycyclic aromatic hydrocarbons trigger human skin cells aging through aryl hydrocarbon receptor, Cysteine-rich protein 61 (CCN1) domain-specific stimulation of matrix metalloproteinase-1 expression through V3 integrin in human skin fibroblasts. The ISSN is used in the postal system and in the publishing world to identify the articles that are published in journals, magazines, newsletters, etc. Tumor necrosis factor-alpha (TNF-) is a pleiotropic immune cytokine that belongs to the TNF superfamily of receptor ligands. Visible blue-violet light degrades carotenoids and generates free radicals and ROS. In the mitochondria, O3 decreases ATP and sirtuin 3, a protein related to the elimination of free radicals. ISO 4 is an international standard which defines a uniform and consistent system for the abbreviation of serial publication titles, which are published regularly. As ISO 4 is an international standard, the abbreviation ('Front. 2016 Nov 17;11(11):CD012437. Figure 1 Frontiers has a community retraction protocol in place to retract papers where serious concerns have been raised and validated by the community that warrant retraction, including ethical concerns, honest errors or scientific misconduct. Cutaneous hypothalamic-pituitary-adrenal axis homolog: regulation by ultraviolet radiation. Multiple logistic regression analysis in patients with RA was conducted to calculate adjusted reporting odds ratios (aRORs) for age, sex, and MTX treatment patterns (MTX alone and combined with FA and TNFi). (2017. b). government site. The Yusho group revealed that several phytochemicals regulate AhR signaling (Mitoma et al., 2018). The International Organization for Standardization 4 (ISO 4) abbreviation of Frontiers in Pharmacology is Front. Accurate knowledge of AhR signaling can generate novel therapies (Esser et al., 2018). Human exposure, even at low POP levels, can, among other things, increase the risk of cancer (Stockholm Convention, 2011). The skin is the first defensive barrier of our body being in contact with the environment. Skobowiat C., Sayre R. M., Dowdy J. C., Slominski A. T. (2013). Researchers consider a number of factors in deciding where to publish their research, such as journal reputation, readership and community, speed of publication, and citations. (2017). Ngoc L. T. N., Park D., Lee Y., Lee Y. C. (2017). Other environmental extrinsic factors also cause skin aging (Krutmann et al., 2017). Both proteins produce superoxide in the presence of the nicotinamide adenine dinucleotide (NADH) and nicotinamide adenine dinucleotide phosphate (NADPH). The h-index of Frontiers in Pharmacology is 129. Prevalence and severity of the skin scars and comedones. BMC Med. Each Frontiers article strives for the highest quality, thanks to genuinely collaborative interactions between authors, editors and reviewers, who include many of the world's best scientists and scholars. NF-B signals increase the expression of proinflammatory genes, MMP inductions, and disbalance in collagen formation (World Health Organization, 2012), and pollutants also disrupt the skin barrier and alter the immunity of the skin. (2017). Environmental factors that influence skin aging and carcinogenesis fall into the following major categories: sun radiation (ultraviolet radiation, visible light, and infra-red radiation), air pollution, tobacco smoke, nutrition, some less well-studied factors, and cosmetic products. The Associate Editor can then personally choose and invite the most appropriate reviewers to handle the peer-review of the manuscript, including Review Editors from the board or external reviewers. 10, 763. Frontiers in Pharmacology 2017 May 8;5(5):CD012657. The small PM can pass into the circulation and damage the dermis, without alterations to the epidermis. With aging, cellular replacement in the skin and mechanical protection continually decreases. Author guidelines Ready to publish? Current Vascular Pharmacology. A simplified representation of the effects of epidermal keratinocyte effects of particulate matter (PM), polycyclic aromatic hydrocarbons (PAH), ozone (O3), and UVR. Meanwhile, electron spin resonance indicated that singlet oxygen and a superoxide radical anion were generated from UVA photoirradiation of B[a]P products in a light-dose responding manner (Xia et al., 2015) ( Field Chief Editor Heike Wulff at UC Davis is supported by an outstanding Editorial Board of international researchers. O3 can activate AhR and transcription factors such as NFkB and inflammatory cytokines. Pharmacological Research publishes cutting-edge articles in biomedical sciences to cover a broad range of topics that move the pharmacological field forward. Before PM (SRM 1648a, mean particle diameter 5.85 m) increased expression of the TRPV1 gene. ). ROS also induce the activation of tumor necrosis factor- (TNF-) and NF-B expression. Table 1 2016 May 13;2016(5):CD012183. After ligand binding, AhR translocates to the nucleus and induces the transcription of cytochrome P450 (CYP 1A1, CYP 1B1). How Uv light touches the brain and endocrine system through skin, and why. Current state of yusho and prospects for therapeutic strategies. Subsequently, the inflammatory processes continue to increase ROS and produce a more significant deterioration of the ECM. Oxidative stress and inflammation are the harmful cutaneous effects of environmental pollution, and more specifically of air pollution. 8600 Rockville Pike Also, DNA can be damaged by the ROS generated during the metabolic activation of PAH (Tsuji et al., 2011) thus owing high toxicity, mutagenic, and/or carcinogenic effects (Idowu et al., 2019). The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (2011). Recently, the in vivo study published by Rudyak et al. Vitamin C compound mixtures prevent ozone-induced oxidative damage in human keratinocytes as initial assessment of pollution protection. This cohort has been used in previous studies on the association between aging skin and air pollution (Vierktter et al., 2010; Vierktter et al., 2015; Hls et al., 2016). Figure 1 Also, B[a]P metabolites produced lipid peroxidation when photoirradiation was done in the presence of lipids. Journal ISSN: 0378-8741. ISSN (Print): 1570-1611. These findings confirm that exposure to PCBs is related to inflammation and that the increase in skin levels of IL-1 might be a risk for developing skin aging. Valacchi G., Muresan X. M., Sticozzi C., Belmonte G., Pecorelli A., Cervellati F., et al. A disproportionality analysis was performed focusing on MTX use and respective adverse events such as interstitial lung disease (ILD), hepatotoxicity, myelosuppression, and tuberculosis (TB), considering all reported cases. In aged skin, in vitro and in vivo studies have proposed that TRPV1 increases (Lee et al., 2016b). However, the senile lentigo appears earlier in the Asian population than in the Caucasian population, so it seems that high air pollution could produce an increase in senile lentigo. NHEK exposed to daily UVA1 (350400 nm) combined with PAH has shown significant synergistic phototoxicity damage. Careers. The coverage history of Frontiers in Pharmacology is as follows 2010-2022. The impact score (IS) 2021 of Vascular Pharmacology is 5.26, which is computed in 2022 as per its definition.Vascular Pharmacology IS is decreased by a factor of 0.05 and approximate percentage change is -0.94% when compared to preceding year 2020, which shows a falling trend. It is based on Scopus data. Although it is known that PM produces inflammation and oxidative stress, no keratinocyte receptor has been linked to those responses. DSC1 is associated with differentiation and keratinization. Some of the stratum corneum lipids also serve as substrates for the enzymatic production of potent antimicrobials (Wertz, 2018). Zamarrn A., Lorrio S., Gonzlez S., Juarranz A. A., Passeron T. (2017). It has been described that cutaneous lesions induced by TCDD are recognized as hamartomas and are found in parallel with atrophy of the sebaceous glands (Mitoma et al., 2015a). Careers. After a certain time frame and if no reviewers have in the meantime been assigned to the manuscript, the Frontiers platform and algorithmic safety-net steps in and invites the most appropriate Review Editors based on constantly updated and improved algorithms that match reviewer expertise with the submitted manuscript. Oxidative stress and DNA damage induce keratinocyte apoptosis, decrease epidermal renewal, and delete wound healing. These signs on aged skin are related to impaired enzymatic processes, partly due to the decrease in the water content of SC (Toni et al., 2017). L-tyrosine and L-dihydroxyphenylalanine as hormone-like regulators of melanocyte functions. The publication country of this journal is Switzerland. FOIA The association of skin aging and air pollution was analyzed in two areas in Beijing with high and low levels of PM2.5, in 400 women with ages that ranged from 40 to 90 years (Peng et al., 2017). Also, O3 depletes the reserves of both enzymatic and non-enzymatic antioxidants in the skin and decreases vitamin C and E levels. , Fundamentals of cutaneous photobiology and photoimmunology, Fitzpatricks Dermatology in General Medicine, An experimental study of the changes in pigmentation in human skin in vivo with visible and near infrared light. The best quartile for Frontiers in Pharmacology is Q1. The AhR target genes encode drug-metabolizing enzymes such as cytochrome P450 (CYP) 1A1, 1A2, and 1B1 as well as proteins that control cell division, apoptosis, and cell differentiation (Esser et al., 2018) ( 2021; 12: 628950. Biologic or tofacitinib monotherapy for rheumatoid arthritis in people with traditional disease-modifying anti-rheumatic drug (DMARD) failure: a Cochrane Systematic Review and network meta-analysis (NMA). NALP3a is a member of the nucleotide-binding oligomerization domain-like receptor (NLR) and senses stress or danger and induces ROS (Martinon, 2010). Additionally, PM stimulation increased the expression of cleaved caspase-3 (Nguyen et al., 2019). Pharmacological Research | Journal | ScienceDirect.com by Elsevier (2016. b). Vierktter A., Schikowski T., Ranft U., Sugiri D., Matsui M., Krmer U., et al. Pollutants induce the production of NALP3a. Exposure to extremely high concentrations of dioxin produces, among others, skin lesions in humans as chloracne. After the contamination in Germany in 2010 by PCB, high serum levels of the contaminant were found in workers at a transformer recycling company in Germany. In vivo relevance for photoprotection by the vitamin D rapid response pathway. (2010). Effects of air pollution and ultraviolet radiation (UVR) on the skin. Zhang W., Jiang P., Chen J., Zhu C., Mao Z., Gao C. (2017. a). Journal of Cardiovascular Pharmacology Impact Score 2022 Prediction IS 2021 of Journal of Cardiovascular Pharmacology is 2.84. (Mitoma et al., 2015a) (

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